APO-SYS Consortium

 

Apoptosis Systems Biology Applied to Cancer and AIDS

 

An integrated approach of experimental biology, data mining, mathematical modeling, biostatistics, system engineering and molecular medicine

Publications     2012  2011  2010  2009   2008   2007        

2012

  1. Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F. Expression of the P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012 Apr 13.

  2. Bangert A, Cristofanon S, Eckhardt I, Abhari BA, Kolodziej S, Häcker S, Vellanki SH, Lausen J, Debatin KM, Fulda S. Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Oncogene. 2012 Jan 23. doi: 10.1038/onc.2011.614.

  3. Bennetzen MV, Mariño G, Pultz D, Morselli E, Færgeman NJ, Kroemer G, Andersen JS. Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers. Cell Cycle. 2012 May 1;11(9).

  4. Bennetzen MV, Cox J, Mann M, Andersen JS. PhosphoSiteAnalyzer: A bioinformatic platform for deciphering phospho proteomes using kinase predictions retrieved from NetworKIN. J Proteome Res. 2012 Apr 3.

  5. Broderick P, Chubb D, Johnson DC, Weinhold N, Försti A, Lloyd A, Olver B, Ma YP, Dobbins SE, Walker BA, Davies FE, Gregory WA, Child JA, Ross FM, Jackson GH, Neben K, Jauch A, Hoffmann P, Mühleisen TW, Nöthen MM, Moebus S, Tomlinson IP, Goldschmidt H, Hemminki* K, Morgan* GJ, Houlston* RS. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat Genet. 2012;44:58-61.

  6. Carafa V, Nebbioso A, Altucci L. Sirtuins and disease: the road ahead. Front Pharmacol. 2012;3:4.

  7. Criollo A, Chereau F, Malik SA, Niso-Santano M, Mariño G, Galluzzi L, Maiuri MC, Baud V, Kroemer G. Autophagy is required for the activation of NFκB. Cell Cycle. 2012 Jan 1;11(1).

  8. Dell'aversana C, Lepore I, Altucci L.HDAC modulation and cell death in the clinic. Exp Cell Res. 2012 Feb 3. 

  9. D'Eletto M, Farrace MG, Rossin F, Strappazzon F, Giacomo GD, Cecconi F, Melino G, Sepe S, Moreno S, Fimia GM, Falasca L, Nardacci R, Piacentini M. Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins. Cell Death Differ. 2012 Feb 10. doi: 10.1038/cdd.2012.2.

  10. Fulda S. Cell death pathways as therapeutic targets in rhabdomyosarcoma. Sarcoma. 2012;2012:326210.

  11. Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov. 2012 Feb 1;11(2):109-24. doi: 10.1038/nrd3627. Review.

  12. Fulda S. Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosis. Exp Cell Res. 2012 Feb 15.

  13. Fulda S. Regulation of apoptosis pathways in cancer stem cells. Cancer Lett. 2012 Mar 16.

  14. Fulda S. Exploiting Inhibitor of Apoptosis (IAP) proteins as therapeutic targets in hematological malignancies. Leukemia. 2012 Jan 9. doi: 10.1038/leu.2012.4.

  15. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012. Jan;19(1):107-20.

  16. Galluzzi L, Morselli E, Kepp O, Vitale I, Younes AB, Maiuri MC, Kroemer G. Evaluation of rapamycin-induced cell death. Methods Mol Biol. 2012;821:125-69.

  17. Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov. 2012 Feb 3;11(3):215-33.

  18. Galluzzi L, Kepp O, Trojel-Hansen C, Kroemer G. Non-apoptotic functions of apoptosis-regulatory proteins. EMBO Rep. 2012 Mar 9. doi: 10.1038/embor.2012.19.

  19. Gonzalez P, Mader I, Tchoghandjian A, Enzenmüller S, Cristofanon S, Basit F, Debatin KM, Fulda S. Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Cell Death Differ. 2012 Feb 17. doi: 10.1038/cdd.2012.10.

  20. Koh GC, Porras P, Aranda B, Hermjakob H, Orchard SE.Analyzing Protein-Protein Interaction Networks (†).J Proteome Res. 2012 Mar 2.

  21. Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 2012 Jan 17. doi: 10.1038/emboj.2011.497.

  22. Hannani D, Ma Y, Yamazaki T, Déchanet-Merville J, Kroemer G, Zitvogel L. Harnessing γδ T cells in anticancer immunotherapy. Trends Immunol. 2012 Feb 22.

  23. Huber HJ, Connolly NM, Dussmann H, Prehn JH. A structured approach to the study of metabolic control principles in intact and impaired mitochondria. Mol Biosyst. 2012 Jan 5.

  24. Huhn S, Pardini B, Naccarati A, Vodicka P, Hemminki K, Försti A. Ancestral susceptibility to colorectal cancer. Mutagenesis. 2012 Mar;27(2):197-204.

  25. Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A. The unfolded protein response at the crossroads of cellular life and death during ER stress. Biol Cell. 2012 Jan 23. doi: 10.1111/boc.201100055.

  26. Kaminskyy V, Zhivotovsky B. Proteases in autophagy. Biochim Biophys Acta. 2012, Jan;1824(1):44-50 .

  27. Karlebach G, Shamir R. Constructing Logical Models of Gene Regulatory Networks by Integrating Transcription Factor-DNA Interactions with Expression Data: An Entropy-Based Approach. J Comput Biol. 2012 Jan;19(1):30-41

  28. Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, Duesbury M, Dumousseau M, Feuermann M, Hinz U, Jandrasits C, Jimenez RC, Khadake J, Mahadevan U, Masson P, Pedruzzi I, Pfeiffenberger E, Porras P, Raghunath A, Roechert B, Orchard S, Hermjakob H. The IntAct molecular interaction database in 2012. Nucleic Acids Res. 2012 Jan;40(1):D841-6.

  29. Kruspig B, Nilchian A, Bejarano I, Orrenius S, Zhivotovsky B, Gogvadze V. Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression. Cell Mol Life Sci. 2012 Jan 28.

  30. Martins I, Michaud M, Sukkurwala AQ, Adjemian S, Ma Y, Shen S, Kepp O, Menger L, Vacchelli E, Galluzzi L, Zitvogel L, Kroemer G. Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death. Autophagy. 2012 Mar 1;8(3).

  31. Maire Al, Alvarez S, Shankaranarayanan P, Lera AR, Bourguet W, Gronemeyer H. Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators. Curr Top Med Chem. 2012 Mar 1;12(6):505-27.

  32. Niso-Santano M, Criollo A, Malik SA, Michaud M, Mariño G, Lachkar S, Galluzzi L, Kroemer G. Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway. Autophagy. 2012 Feb 1;8(2):268-70.

  33. Pagliarini V, Wirawan E, Romagnoli A, Ciccosanti F, Lisi G, Lippens S, Cecconi F, Fimia GM, Vandenabeele P, Corazzari M, Piacentini M. Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. Cell Death Differ. 2012 Mar 23. doi: 10.1038/cdd.2012.27.

  34. Pultz D, Bennetzen MV, Rødkær SV, Zimmermann C, Enserink JM, Andersen JS, Færgeman NJ. Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae. Mol Biosyst. 2012 Jan 4.

  35. Rafn B, Nielsen CF, Andersen SH, Szyniarowski P, Corcelle-Termeau E, Valo E, Fehrenbacher N, Olsen CJ, Daugaard M, Egebjerg C, Bøttzauw T, Kohonen P, Nylandsted J, Hautaniemi S, Moreira J, Jäättelä M, Kallunki T. ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression. Mol Cell. 2012 Mar 30;45(6):764-76.

  36. Ring J, Sommer C, Carmona-Gutierrez D, Ruckenstuhl C, Eisenberg T, Madeo F. The metabolism beyond programmed cell death in yeast. Exp Cell Res. 2012 Mar 27.

  37. Rello-Varona S, Lissa D, Shen S, Niso-Santano M, Senovilla L, Mariño G, Vitale I, Jemaá M, Harper F, Pierron G, Castedo M, Kroemer G. Autophagic removal of micronuclei. Cell Cycle. 2012 Jan 1;11(1).

  38. Sabatino L, Fucci A, Pancione M, Carafa V, Nebbioso A, Pistore C, Babbio F, Votino C, Laudanna C, Ceccarelli M, Altucci L, Bonapace IM, Colantuoni V. UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. Oncogene. 2012 Jan 30. doi: 10.1038/onc.2012.3.

  39. Shen S, Kepp O, Kroemer G. The end of autophagic cell death? Autophagy. 2012 Jan 1;8(1).

  40. Surova O, Akbar NS, Zhivotovsky B. Knock-Down of Core Proteins Regulating MicroRNA Biogenesis Has No Effect on Sensitivity of Lung Cancer Cells to Ionizing Radiation. PLoS One. 2012;7(3):e33134.

  41. Zinovyev A, Fourquet S, Tournier L, Calzone L, Barillot E. Cell death and life in cancer: mathematical modeling of cell fate decisions. Adv Exp Med Biol. 2012;736:261-74.

  42. Zitvogel L, Kepp O, Galluzzi L, Kroemer G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol. 2012 Mar 18;13(4):343-51. doi: 10.1038/ni.2224.

  43. Vanlangenakker N, Vanden Berghe T, Vandenabeele P. Many stimuli pull the necrotic trigger, an overview. Cell Death Differ. 2012 Jan;19(1):75-86.

  44. Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner. Oncogene. 2012 Apr 2. doi: 10.1038/onc.2012.108

  45. Wirawan E, Lippens S, Vanden Berghe T, Romagnoli A, Fimia GM, Piacentini M, Vandenabeele P. Beclin1: A role in membrane dynamics and beyond. Autophagy. 2012 Jan 1;8(1).