APO-SYS Consortium

 

Apoptosis Systems Biology Applied to Cancer and AIDS

 

An integrated approach of experimental biology, data mining, mathematical modeling, biostatistics, system engineering and molecular medicine

Publications    2010  2009   2008   2007         

2008

  1. Alvarez S, Pazos-Randulfe Y, Khanwalkar H, Germain P, Alvarez R, Gronemeyer H, de Lera AR. New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists. Bioorg Med Chem. 2008 Nov 15;16(22):9719-28.

  2. Apetoh L, Tesniere A, Ghiringhelli F, Kroemer G, Zitvogel L. Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies. Cancer Res. 2008 Jun 1; 68(11):4026-30. Review.

  3. Boehrer S, Adès L, Galluzzi L, Tajeddine N, Tailler M, Gardin C, de Botton S, Fenaux P, Kroemer G. Erlotinib and gefitinib for the treatment of myelodysplastic syndrome and acute myeloid leukemia: A preclinical comparison. Biochem Pharmacol. 2008 Jul 8.

  4. Boya P, Kroemer G. Oncogene. Lysosomal membrane permeabilization in cell death. Oncogene 2008 Oct 27;27(50):6434-51. Review.

  5. Dengjel J, Kristensen AR, Andersen JS. Ordered bulk degradation via autophagy. Autophagy. 2008 Nov 20; 4(8).

  6. Duong V, Bret C, Altucci L, Mai A, Duraffourd C, Loubersac J, Harmand PO, Bonnet S, Valente S, Maudelonde T, Cavailles V and Boulle N. Specific activity of class II histone deacetylases in human breast cancer cells.  Mol Cancer Res 2008 Sep.

  7. Di Bernardo G, Squillaro T, Dell'aversana C, Miceli M, Cipollaro M, Cascino A, Altucci L, Galderisi U. Histone Deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells. Stem Cells Dev. 2008 Aug 11.

  8. Fabre C, Grosjean J, Tailler M, Boehrer S, Adès L, Perfettini JL, de Botton S, Fenaux P, Kroemer G. A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts. Cell Cycle. 2008 Jul; 7(14):2139-45.

  9. Fulda S. Caspase-8 in cancer biology and therapy.Cancer Lett. 2008 Dec 24.

  10. Fulda S. Inhibitor of apoptosis proteins in hematological malignancies. Leukemia. 2008 Nov 27.

  11. Galluzzi L, Joza N, Tasdemir E, Maiuri MC, Hengartner M, Abrams JM, Tavernarakis N, Penninger J, Madeo F, Kroemer G. No death without life: vital functions of apoptotic effectors. Cell Death Differ. 2008 Jul;15(7):1113-23. Review.

  12. Galluzzi L, Kepp O, Tajeddine N, Kroemer G. Disruption of the hexokinase-VDAC complex for tumor therapy. Oncogene. 2008 Aug 7; 27(34):4633-5. Epub 2008 May 12.

  13. Galluzzi L, Morselli E, Kepp O, Tajeddine N, Kroemer G. Targeting p53 to mitochondria for cancer therapy. Cell Cycle. 2008 Apr 30;7(13).

  14. Galluzzi L, Morselli E, Kepp O, Kroemer G. Targeting post-mitochondrial effectors of apoptosis for neuroprotection. Biochim Biophys Acta. 2008 Sep 24

  15. Galluzzi L, Vicencio JM, Kepp O, Tasdemir E, Maiuri MC, Kroemer G. To die or not to die: that is the autophagic question. Curr Mol Med. 2008 Mar;8(2):78-91. Review.

  16. Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: what is so special about them? Trends Cell Biol. 2008 Apr;18(4):165-73.Review.

  17. Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria as targets for cancer chemotherapy. Semin Cancer Biol. 2008 Dec 3. Review.

  18. Grosjean-Raillard J, Tailler M, Adès L, Perfettini JL, Fabre C, Braun T, De Botton S, Fenaux P, Kroemer G. ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene. 2008 Dec 15.

  19. Grosjean-Raillard J, Adès L, Boehrer S, Tailler M, Fabre C, Braun T, De Botton S, Israel A, Fenaux P, Kroemer G. Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Apoptosis. 2008 Sep;13(9):1148-61.

  20. Hoffmann J, Vitale I, Buchmann B, Galluzzi L, Schwede W, Senovilla L, Skuballa W, Vivet S, Lichtner RB, Vicencio JM, Panaretakis T, Siemeister G, Lage H, Nanty L, Hammer S, Mittelstaedt K, Winsel S, Eschenbrenner J, Castedo M, Demarche C, Klar U, Kroemer G. Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer Res. 2008 Jul 1; 68(13):5301-8.

  21. Huber HJ, Plchut M, Weisová P, Düssmann H, Wenus J, Rehm M, Ward MW, Prehn JH. TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials. J Neurosci Methods. 2008 Sep 7.

  22. Karlebach G, Shamir R. Modelling and analysis of gene regulatory networks. Nat Rev Mol Cell Biol. 2008 Oct;9(10):770-80. Review.

  23. Kristensen AR, Schandorff S, Hoyer-Hansen M, Nielsen MO, Jaattela M, Dengjel J, Andersen JS. Ordered organelle degradation during starvation-induced autophagy. Mol Cell Proteomics. 2008 Aug 6.

  24. Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell. 2008 Jun; 13(6):472-82. Review.

  25. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2008 Oct 10.

  26. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Inhof A, Mato JM, Esteller M, Fraga MF. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2008 Dec 8.

  27. Levine B, roemer G. Autophagy in the pathogenesis of disease. Cell. 2008 Jan 11; 132(1):27-42. Review

  28. Levine B, inha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy. 2008 Jul 1;4(5):600-6. Epub 2008 May 12. Review.

  29. Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R, Kroemer G. Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ. 2008 Sep 19

  30. Morselli E, Tasdemir E, Maiuri MC, Galluzzi L, Kepp O, Criollo A, Vicencio JM, Soussi T, Kroemer G. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle. 2008 Oct;7(19):3056-61

  31. Norberg E, Gogvadze V, Ott M, Horn M, Uhlén P, Orrenius S, Zhivotovsky B. An increase in intracellular Ca(2+) is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ. 2008 Sep 19.

  32. Opel D, Westhoff MA, Bender A, Braun V, Debatin KM, Fulda S. Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis. Cancer Res. 2008 Aug 1;68(15):6271-80.

  33. Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, Fimia GM, Kepp O, Piacentini M, Froehlich KU, van Endert P, Zitvogel L, Madeo F, Kroemer G. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ. 2008 Sep; 15(9):1499-509.

  34. Pauleau AL, Galluzzi L, Scholz SR, Larochette N, Kepp O, Kroemer G. Unexpected role of the phosphate carrier in mitochondrial fragmentation. Cell Death Differ. 2008 Mar; 15(3):616-8

  35. Perfettini JL, Nardacci R, Bourouba M, Subra F, Gros L, Séror C, Manic G, Rosselli F, Amendola A, Masdehors P, Chessa L, Novelli G, Ojcius DM, Siwicki JK, Chechlinska M, Auclair C, Regueiro JR, de Thé H, Gougeon ML, Piacentini M, Kroemer G. Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. PLoS ONE. 2008 Jun 18; 3(6):e2458.

  36. Radulescu O, Gorban AN, Zinovyev A, Lilienbaum A. Robust simplifications of multiscale biochemical networks. BMC Syst Biol. 2008 Oct 14;2(1):86

  37. Schenck, A. Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A. Habermann, B., Brand, M. and Zerial, M. The endosomal protein APPL1 mediates Akt substrate specificity and cell survival in vertebrate development” Cell  (2008) 133(3): 486-97.

  38. Scognamiglio A, Nebbioso A, Manzo F, Valente S, Mai A, Altucci L. HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2. Biochim Biophys Acta. 2008 Oct;1783(10):2030-8.

  39. Shen J, Vakifahmetoglu H, Stridh H, Zhivotovsky B, Wiman KG. PRIMA-1(MET) induces mitochondrial apoptosis through activation of caspase-2. Oncogene. 2008, Jul 28.

  40. Su H, ebbioso A, Carafa V, Chen Y, Yang B, Altucci L, You Q. Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents. Bioorg Med Chem. 2008 Sep 1;16(17):7992-8002.

  41. Tajeddine N, Galluzzi L, Kepp O, Hangen E, Morselli E, Senovilla L, Araujo N, Pinna G, Larochette N, Zamzami N, Modjtahedi N, Harel-Bellan A, Kroemer G. Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death. Oncogene. 2008 Jul 10; 27(30):4221-32.

  42. Tamm C, Zhivotovsky B, eccatelli S. Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis. Apoptosis. 2008 Mar; 13(3):354-63.

  43. Tasdemir E, Maiuri MC, Orhon I, Kepp O, Morselli E, Criollo A, Kroemer G. p53 represses autophagy in a cell cycle-dependent fashion. Cell Cycle. 2008 Oct;7(19):3006-11

  44. Tasdemir E, Chiara Maiuri M, Morselli E, Criollo A, D'Amelio M, Djavaheri-Mergny M, Cecconi F, Tavernarakis N, Kroemer G. A dual role of p53 in the control of autophagy. Autophagy. 2008 Nov-Dec; 4(6):810-4

  45. Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 2008 Jun; 10:676-87.

  46. Tchatchou S, Jung A, Hemminki K, Sutter C, Wappenschmidt B, Bugert P, Weber BH, Niederacher D, Arnold N, Varon-Mateeva R, Ditsch N, Meindl A, Schmutzler RK, Bartram CR, Burwinkel B. A variant affecting a putative miRNA target site in estrogen receptor one (ERS1) is associated with breast cancer risk in premenopausal women. Carcinogenesis. 2008 Nov 20

  47. Vaculova A, Zhivotovsky B. Chapter eight caspases: determination of their activities in apoptotic cells. Methods Enzymol. 2008; 442:157-81.

  48. Vakifahmetoglu H, Olsson M, Tamm C, Heidari N, Orrenius S, Zhivotovsky B. DNA damage induces two distinct modes of cell death in ovarian carcinomas. Cell Death Differ. 2008 Mar; 15(3):555-66.

  49. Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ. 2008 Jul;15(7):1153-62.Review.

  50. Vandenabeele P, Declercq W, Berghe TV. Necrotic cell death and 'necrostatins': now we can control cellular explosion. Trends Biochem Sci. 2008 Aug; 33(8):352-5.

  51. Vanlangenakker N, Berghe TV, Krysko DV, Festjens N, Vandenabeele P. Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med. 2008 May;8(3):207-20. Review.

  52. Vicencio JM, Galluzzi L, Tajeddine N, Ortiz C, Criollo A, Tasdemir E, Morselli E, Ben Younes A, Maiuri MC, Lavandero S, Kroemer G. Senescence, apoptosis or autophagy? When a damaged cell must decide its path-a mini-review. Gerontology. 2008;54(2):92-9.

  53. Vitale I, enovilla L, Galluzzi L, Criollo A, Vivet S, Castedo M, Kroemer G. Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells. Cell Cycle. 2008 Jul; 7(13):1956-61.

  54. Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M, Gschwend JE, Simmet T, Debatin KM, Fulda S. Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Cancer Res. 2008 Oct 1;68(19):7956-65

  55. Zischka H, Larochette N, Hoffmann F, Hamöller D, Jägemann N, Lichtmannegger J, Jennen L, Müller-Höcker J, Roggel F, Göttlicher M, Vollmar AM, Kroemer G. Electrophoretic analysis of the mitochondrial outer membrane rupture induced by permeability transition. Anal Chem. 2008 Jul 1; 80(13):5051-8.

  56. Zitvogel L, Apetoh L, Ghiringhelli F, André F, Tesniere A, Kroemer G. The anticancer immune response: indispensable for therapeutic success? J Clin Invest. 2008 Jun; 118(6):1991-2001. Review.