APO-SYS Consortium


 

Apoptosis Systems Biology Applied to Cancer and AIDS

 

An integrated approach of experimental biology, data mining, mathematical modeling, biostatistics, system engineering and molecular medicine

APO-SYS Public

Deliverables

DL 4: Training for mastering the interface for pathway map description integration: DL4-apo-sys
DL5: Initial launch of APO-SYS Web server and internal web resources for data sharing and communication:
DL5-apo-sys
DL6: Data
management workshop and workshop report on consortium requirements for sharing of high quality annotation of molecular entities: DL6-apo-sys
DL7: D
ata management workshop and workshop report on consortium requirements for sharing of high-throughput data, definition of standards to be used for all types of data: DL7-apo-sys
DL12: BIOPAX converters for GINsim and ConsensusPathDB:
DL12-apo-sys
DL18: Development of a real-time measurement system for the assessment of caspase8/-10 activation:  DL18-apo-sys
DL20: Systematic explaration and validation of genes affecting mitochondrial-mediated cell death triggered by cisplatin: DL20-apo-sys
DL24: Top-level mathematical model of cell fate decission: DL24-apo-sys
DL33: Synergetic interaction between IAP inhibitors and chemotherapy of TRAIL: Dl33-apo-sys
DL39: Single Cell, real-time measurements of pathways of apoptotic signaling: DL39-apo-sys
DL54: Development of new algorithms to process and model data:
DL54-apo-sys
DL68: In vivo analysis of AIF death pathways in a define murine model: DL68-aposys
DL75: Report on theoretical model studies in different formalisms, including describing qualitative behaviors, robustness and model checking: DL75-aposys

 

News

EU-CORDIS-funded research sheds light on 'shock-and-kill' strategy against HIV-1 -read comment

Europa-Press release Rapid: Fight against cancer: contribution of EU-funded research - read comment

PS Public Service Review: European Union: http://www.publicservice.co.uk nr.20, page 228-229

 WeekendavisenKræftcellernes svage punkt" (Kirkegaard et al.,  2010): http://www.weekendavisen.dk/search/node/hsp70

"Deadline", Danmarks Radio (DR2) (Kirekegaard et al., 2010: http://www.dr.dk/dr2/deadline2230

Time Magazine: "Slowing aging .....with semen" (Eisenberg et al., 2009): http://www.time.com/time/specials/packages/article/0,28804,1963392_1963367_1963387,00.html

Der Spiegel: "Samenflüssigkeit soll Alterung bremsen" (Eisenberg et al., 2009): http://www.spiegel.de/wissenschaft/medizin/0,1518,653348,00.html

Blick: "Sperma hält jung" (Eisenberg et al., 2009): http://www.blick.ch/news/ausland/sperma-bremst-zellalterung-130187

The Telegraph: "Chemical in sperm 'may slow ageing process" (Eisenberg et al., 2009)http://www.telegraph.co.uk/science/science-news/6267901/Chemical-in-sperm-may-slow-ageing-process.html

Internet radio for MDs, Frequency M: Interview of Laurence Calzone, March 4, 2010

National French TV, France 5: Le magazine de la santé. Interview of Emmanuel Barillot and Laurence Calzone March 24, 2010

National radio, France Inter: La tête au carré by C. Tourbe (report of Emmanuel's interview) April 12, 2010

EU-Cordis - Latest research shows how cancer cells react to chemotherapy July 11, 2011: read comment

Karolinska Institutet-news: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 - http://ki.se/ki/jsp/polopoly.jsp?l=sv&d=1666

 

Books

Systems biology analysis of cell death pathways in cancer: how collaborative and interdisciplinary research helps. In Cesario A and Marcus F B (editors) (2011) Cancer Systems Biology: Bioinformatics and Medicine: Research and Clinical Applications. Springer Dordrecht Heidelberg London New York. pp. 267-296.

Understanding different types of cell death using Systems Biology. In: Lavrik I (Editor). Calzone, L., Zinovyev, A., and Zhivotovsky, B. “Systems Biology of apoptosis”. Springer Science, NY, USA, 2012 (In Press).

Different modes of cell death induced by DNA damage. In: Greim H and Albertini R (Editors). Surova, O., and Zhivotovsky, B. “The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens”. RSC Publishing, 2012 (In Press).

Chaouiya C, Naldi A, Thieffry D (2012). "Logical modelling of gene regulatory networks with GINsim." In: van Helden J, Toussaint A, Thieffry D (eds.) Bacterial Molecular Networks, Methods in Molecular Biology series, vol 804, Humana Press, pp. 463-79.

Thieffry D (accepted). “Gene networks”, “logical modelling”, and “regulatory motifs” entries. In: Hancock JM, Zvelebil MJ (eds). Dictionary of Bioinformatics and Computational Biology. New York: John Wiley & Sons.

Fauré A, Thieffry D (in press). "Cell cycle modelling using logical rules." In: Dubitzky W, Wolkenhauer O, Cho K-H, Yokota H (eds.) Encyclopedia of Systems Biology. Springer.